Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
100_EAML_AD	GS_tier2	7.55e-04	1.10e-03	3.11e-05	3.64e-06
GS_tier2	100_EAML_AD	3.10e-10	1.72e-10	9.84e-16	1.61e-14



Evaluating how well 100_EAML_AD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EAML_AD	GS_tier2	0.75	4.51	5.48	3.69	6.08
GS_tier2	100_EAML_AD	0.75	4.81	8.37	4.14	9.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EAML_AD	GS_tier2	0.01	4.71	11.28	8.22	7.15
GS_tier2	100_EAML_AD	0.02	9.06	19.34	9.29	13.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
100_EAML_AD	100	100	
GS_tier2	46	43	IGH;TNSF13;TNSF12