Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
100_EAML_AD	Ismael_GS	4.29e-10	5.47e-11	2.92e-13	2.48e-12
Ismael_GS	100_EAML_AD	2.96e-08	7.01e-08	1.43e-15	1.06e-13



Evaluating how well 100_EAML_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EAML_AD	Ismael_GS	0.94	3.35	6.53	3.61	5.27
Ismael_GS	100_EAML_AD	0.74	4.87	7.55	2.65	7.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EAML_AD	Ismael_GS	0.01	5.46	28.24	7.95	12.87
Ismael_GS	100_EAML_AD	0.02	7.93	12.25	5.92	5.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
100_EAML_AD	100	100	
Ismael_GS	14	14