Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
100_EAML_AD Exclusive	GWAS_GS	4.92e-06	6.42e-03	6.28e-08	2.90e-05
GWAS_GS Exclusive	100_EAML_AD	2.78e-05	4.32e-08	1.14e-09	2.22e-10
100_EAML_AD Exclusive	GWAS_GS Exclusive	6.27e-06	3.04e-03	1.89e-07	5.50e-05
GWAS_GS Exclusive	100_EAML_AD Exclusive	8.53e-05	3.76e-08	6.53e-10	1.15e-09
100_EAML_AD Exclusive	Overlap	5.17e-01	5.17e-01	5.17e-01	1.99e-01
GWAS_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	3.92e-03	2.30e-13	1.95e-73	4.10e-25



Evaluating how well 100_EAML_AD genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EAML_AD Exclusive	GWAS_GS	0.64	3.11	3.41	2.22	5.31
GWAS_GS Exclusive	100_EAML_AD	0.70	3.29	6.12	3.23	7.00
100_EAML_AD Exclusive	GWAS_GS Exclusive	0.64	2.78	3.41	2.58	5.53
GWAS_GS Exclusive	100_EAML_AD Exclusive	0.69	3.04	6.35	3.25	6.38
100_EAML_AD Exclusive	Overlap	0.85	0.27	0.68	0.57	1.80
GWAS_GS Exclusive	Overlap	1.00	2.04	1.60	2.48	2.35
Overlap	Exclusives	0.73	3.91	10.34	2.47	11.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_EAML_AD Exclusive	GWAS_GS	0.01	5.78	4.14	4.59	3.68
GWAS_GS Exclusive	100_EAML_AD	0.02	5.50	14.21	5.91	8.35
100_EAML_AD Exclusive	GWAS_GS Exclusive	0.01	3.82	4.76	5.00	7.61
GWAS_GS Exclusive	100_EAML_AD Exclusive	0.01	4.58	11.15	5.78	10.65
100_EAML_AD Exclusive	Overlap	0.00	1.65	-46.72	6.04	7.75
GWAS_GS Exclusive	Overlap	0.07	102.92	548.38	202.34	86.77
Overlap	Exclusives	0.06	29.75	61.07	14.75	70.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
100_EAML_AD Exclusive	98	98	
GWAS_GS Exclusive	107	102	D21S2088E;SLC8A1-AS1;LINC00158;PCDH11Y;MIR302F
Overlap	2	2