Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
44_cont_genemebed_AD	GS_tier1	8.34e-03	2.51e-01	9.80e-04	2.79e-02
GS_tier1	44_cont_genemebed_AD	1.29e-02	1.46e-06	1.06e-08	2.33e-14



Evaluating how well 44_cont_genemebed_AD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
44_cont_genemebed_AD	GS_tier1	0.67	1.47	1.83	1.43	3.63
GS_tier1	44_cont_genemebed_AD	0.84	1.51	6.60	2.53	8.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
44_cont_genemebed_AD	GS_tier1	0.00	1.45	-5.63	0.42	2.10
GS_tier1	44_cont_genemebed_AD	0.01	0.42	7.41	4.02	12.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
44_cont_genemebed_AD	44	44	
GS_tier1	31	30	MS4A