Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
44_cont_genemebed_AD	GS_tier2	6.38e-02	6.13e-02	6.83e-05	8.58e-05
GS_tier2	44_cont_genemebed_AD	1.28e-05	2.03e-07	2.63e-11	1.38e-14



Evaluating how well 44_cont_genemebed_AD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
44_cont_genemebed_AD	GS_tier2	0.71	3.34	2.97	3.52	4.44
GS_tier2	44_cont_genemebed_AD	0.84	2.83	6.02	2.45	7.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
44_cont_genemebed_AD	GS_tier2	0.00	0.26	3.67	4.78	4.64
GS_tier2	44_cont_genemebed_AD	0.01	3.17	9.11	4.77	10.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
44_cont_genemebed_AD	44	44	
GS_tier2	46	43	TNSF13;TNSF12;IGH