Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
44_cont_genemebed_AD	GWAS_GS	9.45e-03	9.70e-02	8.96e-06	2.32e-04
GWAS_GS	44_cont_genemebed_AD	3.57e-02	1.27e-03	1.07e-05	1.09e-11



Evaluating how well 44_cont_genemebed_AD genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
44_cont_genemebed_AD	GWAS_GS	0.63	1.77	2.53	1.87	4.76
GWAS_GS	44_cont_genemebed_AD	0.83	1.42	4.82	1.98	7.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
44_cont_genemebed_AD	GWAS_GS	0.01	2.23	1.17	2.99	6.54
GWAS_GS	44_cont_genemebed_AD	0.01	0.50	7.19	3.72	15.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
44_cont_genemebed_AD	44	44	
GWAS_GS	109	104	D21S2088E;PCDH11Y;MIR302F;SLC8A1-AS1;LINC00158