Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
44_cont_genemebed_AD	Ismael_GS	4.43e-06	5.31e-09	1.29e-12	2.65e-10
Ismael_GS	44_cont_genemebed_AD	1.21e-03	6.59e-05	2.14e-07	6.54e-12



Evaluating how well 44_cont_genemebed_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
44_cont_genemebed_AD	Ismael_GS	0.91	4.00	4.45	2.97	5.72
Ismael_GS	44_cont_genemebed_AD	0.83	2.35	5.31	1.92	8.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
44_cont_genemebed_AD	Ismael_GS	0.00	1.85	9.12	4.58	10.44
Ismael_GS	44_cont_genemebed_AD	0.01	7.06	11.85	5.21	15.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
44_cont_genemebed_AD	44	44	
Ismael_GS	14	14