Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
100_cont_genemebed_AD	GS_tier1	3.77e-03	1.06e-01	6.11e-05	2.04e-03
GS_tier1	100_cont_genemebed_AD	5.12e-06	1.23e-12	7.08e-17	2.88e-23



Evaluating how well 100_cont_genemebed_AD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_cont_genemebed_AD	GS_tier1	0.71	3.27	2.95	1.94	3.80
GS_tier1	100_cont_genemebed_AD	0.82	2.15	8.88	2.92	10.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_cont_genemebed_AD	GS_tier1	0.00	6.65	-5.58	4.36	5.30
GS_tier1	100_cont_genemebed_AD	0.02	1.57	12.51	5.38	20.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
100_cont_genemebed_AD	100	100	
GS_tier1	31	30	MS4A