Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
100_cont_genemebed_AD Exclusive	Ismael_GS	4.55e-04	7.87e-06	2.35e-11	8.85e-10
Ismael_GS Exclusive	100_cont_genemebed_AD	1.65e-04	1.16e-06	2.73e-12	6.31e-23
100_cont_genemebed_AD Exclusive	Ismael_GS Exclusive	4.93e-04	9.56e-07	6.41e-13	1.37e-08
Ismael_GS Exclusive	100_cont_genemebed_AD Exclusive	4.05e-04	5.59e-07	7.73e-09	9.34e-23
100_cont_genemebed_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	5.94e-02
Ismael_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.89e-24	5.50e-18	3.36e-73	2.58e-40



Evaluating how well 100_cont_genemebed_AD genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_cont_genemebed_AD Exclusive	Ismael_GS	0.91	2.58	4.74	3.15	5.18
Ismael_GS Exclusive	100_cont_genemebed_AD	0.81	2.39	7.06	2.23	10.16
100_cont_genemebed_AD Exclusive	Ismael_GS Exclusive	0.90	2.86	4.71	3.14	5.05
Ismael_GS Exclusive	100_cont_genemebed_AD Exclusive	0.81	2.08	7.45	1.75	10.26
100_cont_genemebed_AD Exclusive	Overlap	0.99	0.61	inf	0.85	1.57
Ismael_GS Exclusive	Overlap	1.00	1.49	287270478041790.00	1.66	1.61
Overlap	Exclusives	0.86	inf	10.23	1.84	13.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_cont_genemebed_AD Exclusive	Ismael_GS	0.00	1.57	9.75	4.18	12.56
Ismael_GS Exclusive	100_cont_genemebed_AD	0.02	5.98	13.21	5.72	20.99
100_cont_genemebed_AD Exclusive	Ismael_GS Exclusive	0.00	1.94	7.34	6.53	9.98
Ismael_GS Exclusive	100_cont_genemebed_AD Exclusive	0.02	4.45	10.87	4.05	21.28
100_cont_genemebed_AD Exclusive	Overlap	0.00	-0.13	57643574579486768.00	1.46	3.22
Ismael_GS Exclusive	Overlap	0.01	36.89	215926515558630240.00	26.36	44.28
Overlap	Exclusives	0.03	inf	25.45	2.02	17.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
100_cont_genemebed_AD Exclusive	99	99	
Ismael_GS Exclusive	13	13	
Overlap	1	1