Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
100_cont_genemebed_AD Exclusive	GWAS_GS	3.96e-03	3.58e-02	3.77e-09	1.29e-04
GWAS_GS Exclusive	100_cont_genemebed_AD	2.90e-03	1.37e-06	3.71e-10	3.16e-22
100_cont_genemebed_AD Exclusive	GWAS_GS Exclusive	4.69e-03	3.60e-02	3.94e-09	3.64e-04
GWAS_GS Exclusive	100_cont_genemebed_AD Exclusive	4.39e-03	2.73e-06	2.88e-10	8.27e-22
100_cont_genemebed_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	5.94e-02
GWAS_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	6.65e-24	9.27e-18	1.41e-96	1.73e-37



Evaluating how well 100_cont_genemebed_AD genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_cont_genemebed_AD Exclusive	GWAS_GS	0.63	2.42	2.18	2.02	4.72
GWAS_GS Exclusive	100_cont_genemebed_AD	0.80	1.50	6.84	2.74	10.64
100_cont_genemebed_AD Exclusive	GWAS_GS Exclusive	0.63	2.45	2.08	2.58	4.30
GWAS_GS Exclusive	100_cont_genemebed_AD Exclusive	0.80	1.39	6.52	2.67	8.66
100_cont_genemebed_AD Exclusive	Overlap	0.99	0.62	inf	0.69	1.61
GWAS_GS Exclusive	Overlap	1.00	0.91	447082915191147.00	0.94	1.66
Overlap	Exclusives	0.78	1700263827443533.00	10.52	2.14	13.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
100_cont_genemebed_AD Exclusive	GWAS_GS	0.01	2.78	0.82	3.80	6.67
GWAS_GS Exclusive	100_cont_genemebed_AD	0.02	0.96	14.47	4.68	14.24
100_cont_genemebed_AD Exclusive	GWAS_GS Exclusive	0.01	3.22	0.53	3.88	5.74
GWAS_GS Exclusive	100_cont_genemebed_AD Exclusive	0.02	0.85	11.21	5.22	15.82
100_cont_genemebed_AD Exclusive	Overlap	0.00	0.03	57643574579486768.00	0.44	4.25
GWAS_GS Exclusive	Overlap	0.02	2.55	396244643163198016.00	9.29	7.88
Overlap	Exclusives	0.03	3456143053383976.50	19.20	2.26	25.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
100_cont_genemebed_AD Exclusive	99	99	
GWAS_GS Exclusive	108	103	MIR302F;PCDH11Y;D21S2088E;SLC8A1-AS1;LINC00158
Overlap	1	1