Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_R4_control1 Exclusive	TIER1_GS	4.45e-09	2.12e-10	1.73e-10	1.34e-11
TIER1_GS Exclusive	Sigma_EA_R4_control1	3.06e-01	3.34e-01	6.74e-02	1.11e-01
Sigma_EA_R4_control1 Exclusive	TIER1_GS Exclusive	2.44e-07	1.10e-08	1.04e-08	2.66e-09
TIER1_GS Exclusive	Sigma_EA_R4_control1 Exclusive	6.31e-01	5.97e-01	1.22e-01	1.10e-01
Sigma_EA_R4_control1 Exclusive	Overlap	7.47e-03	8.41e-03	3.88e-03	5.78e-04
TIER1_GS Exclusive	Overlap	1.83e-09	2.30e-07	9.14e-09	2.74e-08
Overlap	Exclusives	9.41e-06	4.79e-07	6.73e-18	8.84e-08



Evaluating how well Sigma_EA_R4_control1 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R4_control1 Exclusive	TIER1_GS	0.88	5.06	7.22	4.04	6.65
TIER1_GS Exclusive	Sigma_EA_R4_control1	0.56	1.86	1.73	1.54	2.06
Sigma_EA_R4_control1 Exclusive	TIER1_GS Exclusive	0.86	4.42	7.02	3.79	6.56
TIER1_GS Exclusive	Sigma_EA_R4_control1 Exclusive	0.54	1.38	0.84	1.26	1.88
Sigma_EA_R4_control1 Exclusive	Overlap	0.97	3.03	3.55	3.00	3.32
TIER1_GS Exclusive	Overlap	1.00	3.16	2.87	2.91	3.94
Overlap	Exclusives	0.65	3.83	6.96	3.45	6.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R4_control1 Exclusive	TIER1_GS	0.05	54.85	103.65	51.35	10.60
TIER1_GS Exclusive	Sigma_EA_R4_control1	0.03	40.00	40.52	36.48	34.87
Sigma_EA_R4_control1 Exclusive	TIER1_GS Exclusive	0.03	42.85	53.12	34.74	70.42
TIER1_GS Exclusive	Sigma_EA_R4_control1 Exclusive	0.03	20.53	25.25	25.96	28.15
Sigma_EA_R4_control1 Exclusive	Overlap	0.06	134.21	264.43	174.74	95.16
TIER1_GS Exclusive	Overlap	0.08	198.65	122.27	160.99	263.37
Overlap	Exclusives	0.08	70.90	113.45	56.06	99.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_R4_control1 Exclusive	133	128	TNFSF12-TNFSF13;CCDC187;DUXB;TAF11L13;CHURC1-FNTB
TIER1_GS Exclusive	27	26	MS4A
Overlap	4	4