Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma non-coding_control1 Exclusive	TIER1_GS	9.58e-02	8.42e-02	5.86e-02	3.58e-04
TIER1_GS Exclusive	Sigma non-coding_control1	2.10e-01	7.53e-01	2.55e-01	3.62e-01
Sigma non-coding_control1 Exclusive	TIER1_GS Exclusive	1.97e-01	1.78e-01	1.16e-01	4.23e-03
TIER1_GS Exclusive	Sigma non-coding_control1 Exclusive	2.07e-01	9.66e-01	6.61e-01	5.54e-01
Sigma non-coding_control1 Exclusive	Overlap	7.14e-01	5.71e-01	7.46e-01	1.07e-01
TIER1_GS Exclusive	Overlap	1.83e-09	9.58e-05	9.14e-09	9.05e-07
Overlap	Exclusives	5.41e-02	6.15e-02	1.22e-08	1.17e-02



Evaluating how well Sigma non-coding_control1 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma non-coding_control1 Exclusive	TIER1_GS	0.71	1.96	3.00	1.75	4.47
TIER1_GS Exclusive	Sigma non-coding_control1	0.53	0.42	0.82	0.76	1.37
Sigma non-coding_control1 Exclusive	TIER1_GS Exclusive	0.71	1.52	3.20	1.80	3.64
TIER1_GS Exclusive	Sigma non-coding_control1 Exclusive	0.52	-0.08	0.21	0.10	0.87
Sigma non-coding_control1 Exclusive	Overlap	0.71	0.23	0.10	0.20	1.28
TIER1_GS Exclusive	Overlap	0.99	3.10	3.31	3.34	3.22
Overlap	Exclusives	0.57	2.21	3.14	2.05	3.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma non-coding_control1 Exclusive	TIER1_GS	0.00	2.19	4.16	1.84	0.48
TIER1_GS Exclusive	Sigma non-coding_control1	0.01	3.23	2.83	4.31	3.88
Sigma non-coding_control1 Exclusive	TIER1_GS Exclusive	0.00	1.45	4.51	2.83	3.16
TIER1_GS Exclusive	Sigma non-coding_control1 Exclusive	0.01	0.68	1.24	0.64	1.49
Sigma non-coding_control1 Exclusive	Overlap	0.00	-0.39	-0.71	-0.37	-0.10
TIER1_GS Exclusive	Overlap	0.03	116.12	33.89	124.26	86.95
Overlap	Exclusives	0.04	35.85	30.56	34.13	43.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma non-coding_control1 Exclusive	187	181	PRAMEF15;MRPL23;LINC02210-CRHR1;ZNF511-PRAP1;AC005779.2;AL451062.3
TIER1_GS Exclusive	27	26	MS4A
Overlap	4	4