Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma non-coding_control1 Exclusive	Tier2_gs	9.51e-01	9.01e-01	9.04e-01	5.65e-02
Tier2_gs Exclusive	Sigma non-coding_control1	3.40e-01	7.61e-01	2.32e-03	3.92e-01
Sigma non-coding_control1 Exclusive	Tier2_gs Exclusive	9.72e-01	9.16e-01	8.99e-01	8.63e-02
Tier2_gs Exclusive	Sigma non-coding_control1 Exclusive	2.61e-01	6.71e-01	1.68e-03	3.57e-01
Sigma non-coding_control1 Exclusive	Overlap	9.90e-01	6.93e-01	7.72e-01	2.57e-01
Tier2_gs Exclusive	Overlap	5.54e-01	7.72e-01	6.93e-01	8.32e-01
Overlap	Exclusives	6.53e-01	9.82e-01	2.34e-09	4.02e-01



Evaluating how well Sigma non-coding_control1 genes are linked to Tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma non-coding_control1 Exclusive	Tier2_gs	0.59	-0.39	-0.20	-0.19	2.22
Tier2_gs Exclusive	Sigma non-coding_control1	0.52	0.29	-0.09	0.05	0.71
Sigma non-coding_control1 Exclusive	Tier2_gs Exclusive	0.59	-0.19	-0.21	-0.40	1.92
Tier2_gs Exclusive	Sigma non-coding_control1 Exclusive	0.52	0.04	-0.14	0.02	0.72
Sigma non-coding_control1 Exclusive	Overlap	0.82	0.16	0.80	0.42	1.33
Tier2_gs Exclusive	Overlap	0.54	-0.46	-0.68	-0.80	0.20
Overlap	Exclusives	0.53	-0.34	0.06	-0.20	1.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma non-coding_control1 Exclusive	Tier2_gs	0.00	0.35	2.10	1.32	6.41
Tier2_gs Exclusive	Sigma non-coding_control1	0.01	0.11	-0.28	0.05	-0.03
Sigma non-coding_control1 Exclusive	Tier2_gs Exclusive	0.00	0.51	2.07	0.93	5.22
Tier2_gs Exclusive	Sigma non-coding_control1 Exclusive	0.01	-0.20	-0.22	-0.08	0.31
Sigma non-coding_control1 Exclusive	Overlap	0.00	-0.34	0.23	-0.25	0.01
Tier2_gs Exclusive	Overlap	0.00	-0.30	-0.59	-0.63	-0.26
Overlap	Exclusives	0.01	-0.27	-0.30	-0.29	0.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma non-coding_control1 Exclusive	190	184	LINC02210-CRHR1;ZNF511-PRAP1;AC005779.2;PRAMEF15;MRPL23;AL451062.3
Tier2_gs Exclusive	45	42	TNSF12;IGH;TNSF13
Overlap	1	1