Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
42_epilepsy	FUMA1_GS	4.92e-01	4.24e-01	7.07e-01	1.94e-01
FUMA1_GS	42_epilepsy	8.50e-01	8.89e-01	3.68e-01	9.05e-01



Evaluating how well 42_epilepsy genes are linked to FUMA1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
42_epilepsy	FUMA1_GS	0.61	0.66	0.82	0.42	1.64
FUMA1_GS	42_epilepsy	0.50	0.22	-0.15	-0.01	0.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
42_epilepsy	FUMA1_GS	0.00	0.20	-0.02	-0.11	0.09
FUMA1_GS	42_epilepsy	0.00	-0.08	-0.32	-0.23	-0.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
42_epilepsy	42	41	DPEP2NB
FUMA1_GS	19	18	LINC02356