Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
42_epilepsy	FUMA_set2	6.27e-01	7.19e-01	7.73e-01	1.86e-01
FUMA_set2	42_epilepsy	9.03e-01	9.98e-01	2.32e-01	9.26e-01



Evaluating how well 42_epilepsy genes are linked to FUMA_set2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
42_epilepsy	FUMA_set2	0.57	0.66	0.60	0.51	1.08
FUMA_set2	42_epilepsy	0.49	-0.22	-0.11	-0.38	-0.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
42_epilepsy	FUMA_set2	0.00	-0.25	-0.28	-0.31	-0.13
FUMA_set2	42_epilepsy	0.00	-0.16	-0.26	-0.32	-0.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
42_epilepsy	42	41	DPEP2NB
FUMA_set2	21	18	LINC00558;MIR548H4;ADPGK-AS1