Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
42_epilepsy	meta_GWAS	5.45e-02	7.76e-02	4.39e-02	3.56e-01
meta_GWAS	42_epilepsy	2.07e-02	1.23e-01	1.26e-01	1.96e-01



Evaluating how well 42_epilepsy genes are linked to meta_GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
42_epilepsy	meta_GWAS	0.52	-1.21	-1.48	-1.03	0.44
meta_GWAS	42_epilepsy	0.46	-1.01	-0.89	-1.12	-0.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
42_epilepsy	meta_GWAS	0.00	-0.91	-0.84	-0.79	-0.38
meta_GWAS	42_epilepsy	0.00	-0.78	-0.82	-0.49	-0.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
42_epilepsy	42	41	DPEP2NB
meta_GWAS	29	29