Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 42_epilepsy meta_GWAS 5.45e-02 7.76e-02 4.39e-02 3.56e-01 meta_GWAS 42_epilepsy 2.07e-02 1.23e-01 1.26e-01 1.96e-01 Evaluating how well 42_epilepsy genes are linked to meta_GWAS genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 42_epilepsy meta_GWAS 0.52 -1.21 -1.48 -1.03 0.44 meta_GWAS 42_epilepsy 0.46 -1.01 -0.89 -1.12 -0.86 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 42_epilepsy meta_GWAS 0.00 -0.91 -0.84 -0.79 -0.38 meta_GWAS 42_epilepsy 0.00 -0.78 -0.82 -0.49 -0.24 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 42_epilepsy 42 41 DPEP2NB meta_GWAS 29 29