Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
142_pos_epilepsy Exclusive	FUMA1	3.71e-01	3.46e-01	4.13e-01	2.14e-01
FUMA1 Exclusive	142_pos_epilepsy	4.25e-01	3.52e-01	7.33e-03	2.85e-01
142_pos_epilepsy Exclusive	FUMA1 Exclusive	6.03e-01	5.03e-01	6.52e-01	2.50e-01
FUMA1 Exclusive	142_pos_epilepsy Exclusive	4.59e-01	3.45e-01	1.03e-02	3.99e-01
142_pos_epilepsy Exclusive	Overlap	3.96e-02	3.37e-01	5.94e-02	5.94e-02
FUMA1 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.31e-02	6.08e-03	2.05e-12	1.42e-02



Evaluating how well 142_pos_epilepsy genes are linked to FUMA1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
142_pos_epilepsy Exclusive	FUMA1	0.63	0.91	0.74	0.91	2.14
FUMA1 Exclusive	142_pos_epilepsy	0.51	0.86	0.95	0.79	0.62
142_pos_epilepsy Exclusive	FUMA1 Exclusive	0.61	0.79	0.77	0.68	1.60
FUMA1 Exclusive	142_pos_epilepsy Exclusive	0.51	0.88	0.93	0.86	0.33
142_pos_epilepsy Exclusive	Overlap	0.97	1.90	1.55	1.55	1.68
FUMA1 Exclusive	Overlap	1.00	1.59	1.78	2.12	1.43
Overlap	Exclusives	0.59	2.15	4.65	3.00	4.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
142_pos_epilepsy Exclusive	FUMA1	0.00	1.11	2.14	0.67	2.39
FUMA1 Exclusive	142_pos_epilepsy	0.01	1.60	1.68	0.83	0.81
142_pos_epilepsy Exclusive	FUMA1 Exclusive	0.00	1.51	2.41	0.77	0.68
FUMA1 Exclusive	142_pos_epilepsy Exclusive	0.01	0.40	0.97	0.94	0.30
142_pos_epilepsy Exclusive	Overlap	0.00	5.01	1.48	2.09	2.77
FUMA1 Exclusive	Overlap	0.04	34.79	38.98	130.39	44.60
Overlap	Exclusives	0.01	1.39	11.06	5.65	4.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
142_pos_epilepsy Exclusive	141	140	DPEP2NB
FUMA1 Exclusive	18	17	LINC02356
Overlap	1	1