Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
142_pos_epilepsy	FUMA2	5.76e-01	3.65e-01	7.03e-01	2.02e-01
FUMA2	142_pos_epilepsy	7.55e-02	3.15e-01	1.72e-02	8.16e-01



Evaluating how well 142_pos_epilepsy genes are linked to FUMA2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
142_pos_epilepsy	FUMA2	0.60	1.04	1.21	0.84	1.65
FUMA2	142_pos_epilepsy	0.51	1.28	1.05	0.51	0.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
142_pos_epilepsy	FUMA2	0.00	0.16	1.57	0.18	1.14
FUMA2	142_pos_epilepsy	0.01	0.74	0.35	0.06	0.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
142_pos_epilepsy	142	141	DPEP2NB
FUMA2	21	18	LINC00558;MIR548H4;ADPGK-AS1