Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
21_neg_epilepsy	FUMA1	7.99e-01	5.64e-01	7.23e-01	2.53e-01
FUMA1	21_neg_epilepsy	3.80e-01	7.10e-01	9.78e-01	7.14e-01



Evaluating how well 21_neg_epilepsy genes are linked to FUMA1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
21_neg_epilepsy	FUMA1	0.60	-0.32	0.06	-0.22	1.54
FUMA1	21_neg_epilepsy	0.49	-0.43	-0.42	-0.65	-0.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
21_neg_epilepsy	FUMA1	0.00	-0.32	-0.17	-0.28	-0.09
FUMA1	21_neg_epilepsy	0.00	-0.18	-0.35	-0.40	-0.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
21_neg_epilepsy	21	21	
FUMA1	19	18	LINC02356