Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
21_neg_epilepsy	FUMA2	4.55e-01	4.48e-01	3.71e-01	1.84e-01
FUMA2	21_neg_epilepsy	6.81e-01	6.95e-01	4.96e-01	8.15e-01



Evaluating how well 21_neg_epilepsy genes are linked to FUMA2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
21_neg_epilepsy	FUMA2	0.57	0.21	0.18	0.31	0.98
FUMA2	21_neg_epilepsy	0.48	-0.52	-0.45	-0.60	-0.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
21_neg_epilepsy	FUMA2	0.00	-0.49	-0.62	-0.36	-0.14
FUMA2	21_neg_epilepsy	0.00	-0.58	-0.58	-0.69	-0.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
21_neg_epilepsy	21	21	
FUMA2	21	18	LINC00558;MIR548H4;ADPGK-AS1