Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
21_neg_epilepsy	meta_GWAS	8.70e-01	6.33e-01	9.36e-01	4.82e-02
meta_GWAS	21_neg_epilepsy	7.33e-02	4.89e-01	3.72e-01	4.17e-01



Evaluating how well 21_neg_epilepsy genes are linked to meta_GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
21_neg_epilepsy	meta_GWAS	0.58	-0.38	-0.70	-0.27	1.42
meta_GWAS	21_neg_epilepsy	0.47	-0.91	-0.62	-0.82	-0.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
21_neg_epilepsy	meta_GWAS	0.00	-0.54	-0.74	-0.47	0.08
meta_GWAS	21_neg_epilepsy	0.00	-0.53	-0.35	-0.43	-0.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
21_neg_epilepsy	21	21	
meta_GWAS	29	29