Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 101_AD_UKB Exclusive 45_AD_union_Olink 1.33e-01 5.60e-03 1.59e-03 5.11e-08 45_AD_union_Olink Exclusive 101_AD_UKB 3.02e-02 1.84e-01 1.48e-02 1.00e-02 101_AD_UKB Exclusive 45_AD_union_Olink Exclusive 1.64e-01 7.19e-03 3.21e-03 4.19e-07 45_AD_union_Olink Exclusive 101_AD_UKB Exclusive 6.83e-02 1.84e-01 3.27e-02 1.57e-02 101_AD_UKB Exclusive Overlap 9.85e-05 9.85e-05 2.96e-04 1.48e-03 45_AD_union_Olink Exclusive Overlap 5.91e-04 9.85e-04 9.85e-05 2.07e-03 Overlap Exclusives 1.31e-07 6.74e-07 1.75e-26 1.48e-11 Evaluating how well 101_AD_UKB genes are linked to 45_AD_union_Olink genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 101_AD_UKB Exclusive 45_AD_union_Olink 0.74 1.14 3.55 2.03 6.28 45_AD_union_Olink Exclusive 101_AD_UKB 0.59 2.34 2.17 2.15 2.89 101_AD_UKB Exclusive 45_AD_union_Olink Exclusive 0.73 1.13 3.23 1.85 5.43 45_AD_union_Olink Exclusive 101_AD_UKB Exclusive 0.58 2.62 1.40 1.57 3.01 101_AD_UKB Exclusive Overlap 1.00 1.81 2.20 1.88 2.29 45_AD_union_Olink Exclusive Overlap 0.98 1.69 2.40 1.85 2.19 Overlap Exclusives 0.67 2.58 6.23 2.18 7.26 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 101_AD_UKB Exclusive 45_AD_union_Olink 0.01 1.80 11.03 3.63 12.19 45_AD_union_Olink Exclusive 101_AD_UKB 0.01 3.16 1.92 3.38 4.16 101_AD_UKB Exclusive 45_AD_union_Olink Exclusive 0.01 0.53 4.00 2.01 4.99 45_AD_union_Olink Exclusive 101_AD_UKB Exclusive 0.01 2.40 0.86 2.09 1.43 101_AD_UKB Exclusive Overlap 0.02 37.62 94.31 27.55 1.15 45_AD_union_Olink Exclusive Overlap 0.00 1.03 18.14 16.41 17.81 Overlap Exclusives 0.02 9.49 17.39 5.23 10.58 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 101_AD_UKB Exclusive 99 99 45_AD_union_Olink Exclusive 43 43 Overlap 2 2