Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
223_pEA_EAML Exclusive	GS_tier1	1.09e-09	7.46e-11	1.06e-09	1.27e-12
GS_tier1 Exclusive	223_pEA_EAML	1.80e-01	4.59e-01	8.19e-02	3.36e-01
223_pEA_EAML Exclusive	GS_tier1 Exclusive	4.46e-10	2.06e-11	9.35e-10	4.08e-11
GS_tier1 Exclusive	223_pEA_EAML Exclusive	2.00e-01	6.14e-01	1.93e-01	3.23e-01
223_pEA_EAML Exclusive	Overlap	1.11e-01	7.76e-01	9.71e-02	9.71e-02
GS_tier1 Exclusive	Overlap	4.36e-07	8.71e-06	4.36e-06	7.19e-05
Overlap	Exclusives	5.61e-03	1.44e-04	1.20e-18	8.97e-05



Evaluating how well 223_pEA_EAML genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
223_pEA_EAML Exclusive	GS_tier1	0.86	4.43	6.97	4.33	6.04
GS_tier1 Exclusive	223_pEA_EAML	0.50	1.32	0.83	0.83	-0.16
223_pEA_EAML Exclusive	GS_tier1 Exclusive	0.87	3.71	7.63	4.30	5.82
GS_tier1 Exclusive	223_pEA_EAML Exclusive	0.49	0.95	0.65	0.50	-0.36
223_pEA_EAML Exclusive	Overlap	0.81	1.57	1.43	1.81	1.76
GS_tier1 Exclusive	Overlap	0.99	3.43	3.01	2.92	2.64
Overlap	Exclusives	0.57	2.11	5.29	2.77	3.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
223_pEA_EAML Exclusive	GS_tier1	0.01	10.93	6.71	12.21	24.26
GS_tier1 Exclusive	223_pEA_EAML	0.02	9.75	13.98	8.71	9.39
223_pEA_EAML Exclusive	GS_tier1 Exclusive	0.01	9.82	7.51	10.80	16.27
GS_tier1 Exclusive	223_pEA_EAML Exclusive	0.02	6.91	7.85	5.32	6.33
223_pEA_EAML Exclusive	Overlap	0.00	8.75	14.02	9.73	0.03
GS_tier1 Exclusive	Overlap	0.04	155.31	87.17	117.55	50.48
Overlap	Exclusives	0.04	23.22	24.64	15.57	27.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
223_pEA_EAML Exclusive	220	216	C17orf113;FOXL2NB;CHD2;TM9SF1
GS_tier1 Exclusive	28	27	MS4A
Overlap	3	3