Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
223_pEA_EAML Exclusive	GS_tier2	2.55e-02	1.99e-03	1.51e-02	5.43e-05
GS_tier2 Exclusive	223_pEA_EAML	3.20e-01	3.48e-01	2.08e-03	5.18e-01
223_pEA_EAML Exclusive	GS_tier2 Exclusive	3.98e-02	1.89e-03	2.56e-02	1.63e-04
GS_tier2 Exclusive	223_pEA_EAML Exclusive	3.97e-01	3.72e-01	6.57e-04	4.22e-01
223_pEA_EAML Exclusive	Overlap	1.39e-01	1.98e-02	4.75e-01	2.18e-01
GS_tier2 Exclusive	Overlap	3.96e-02	1.98e-02	5.94e-02	1.19e-01
Overlap	Exclusives	8.72e-07	1.60e-01	2.43e-43	1.95e-01



Evaluating how well 223_pEA_EAML genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
223_pEA_EAML Exclusive	GS_tier2	0.67	1.29	2.94	2.01	4.12
GS_tier2 Exclusive	223_pEA_EAML	0.51	1.59	0.97	0.97	0.55
223_pEA_EAML Exclusive	GS_tier2 Exclusive	0.67	0.99	3.07	1.85	3.30
GS_tier2 Exclusive	223_pEA_EAML Exclusive	0.51	1.42	1.17	1.27	0.61
223_pEA_EAML Exclusive	Overlap	0.96	1.05	1.13	0.73	1.34
GS_tier2 Exclusive	Overlap	0.94	2.16	2.93	1.11	1.73
Overlap	Exclusives	0.53	5.71	2.35	0.83	1.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
223_pEA_EAML Exclusive	GS_tier2	0.01	1.44	2.94	2.35	6.96
GS_tier2 Exclusive	223_pEA_EAML	0.01	3.48	3.39	2.49	2.94
223_pEA_EAML Exclusive	GS_tier2 Exclusive	0.01	1.14	2.89	1.94	4.60
GS_tier2 Exclusive	223_pEA_EAML Exclusive	0.01	2.40	3.77	3.33	2.77
223_pEA_EAML Exclusive	Overlap	0.00	0.70	2.03	-0.06	0.14
GS_tier2 Exclusive	Overlap	0.00	0.64	10.13	0.85	0.45
Overlap	Exclusives	0.02	3.65	2.71	0.83	1.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
223_pEA_EAML Exclusive	222	218	TM9SF1;C17orf113;FOXL2NB;CHD2
GS_tier2 Exclusive	45	42	TNSF13;IGH;TNSF12
Overlap	1	1