Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
223_pEA_EAML	Ismael_GS	4.12e-01	2.56e-01	4.01e-01	8.77e-03
Ismael_GS	223_pEA_EAML	5.03e-02	6.73e-01	1.11e-05	3.61e-01



Evaluating how well 223_pEA_EAML genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
223_pEA_EAML	Ismael_GS	0.78	1.39	2.50	1.32	3.92
Ismael_GS	223_pEA_EAML	0.49	0.54	0.43	0.32	-0.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
223_pEA_EAML	Ismael_GS	0.00	1.08	1.37	2.05	1.38
Ismael_GS	223_pEA_EAML	0.01	1.63	1.75	0.73	1.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
223_pEA_EAML	223	219	FOXL2NB;C17orf113;CHD2;TM9SF1
Ismael_GS	14	14