Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
223_pEA_EAML Exclusive	GWAS	1.66e-01	9.61e-02	6.67e-01	1.28e-03
GWAS Exclusive	223_pEA_EAML	3.98e-01	7.02e-01	5.35e-02	5.38e-01
223_pEA_EAML Exclusive	GWAS Exclusive	1.51e-01	1.26e-01	5.39e-01	4.09e-03
GWAS Exclusive	223_pEA_EAML Exclusive	5.10e-01	8.44e-01	2.64e-01	3.43e-01
223_pEA_EAML Exclusive	Overlap	8.68e-01	6.33e-01	6.89e-01	8.98e-02
GWAS Exclusive	Overlap	8.02e-04	1.17e-02	2.69e-04	1.59e-03
Overlap	Exclusives	1.39e-03	8.29e-04	2.13e-15	1.84e-05



Evaluating how well 223_pEA_EAML genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
223_pEA_EAML Exclusive	GWAS	0.60	0.87	1.76	0.83	3.95
GWAS Exclusive	223_pEA_EAML	0.49	0.85	0.51	0.39	-0.36
223_pEA_EAML Exclusive	GWAS Exclusive	0.59	0.99	1.37	0.94	3.20
GWAS Exclusive	223_pEA_EAML Exclusive	0.48	0.76	0.08	-0.09	-0.89
223_pEA_EAML Exclusive	Overlap	0.69	0.41	1.03	1.09	2.03
GWAS Exclusive	Overlap	0.78	2.28	2.27	2.57	2.78
Overlap	Exclusives	0.58	3.71	5.21	3.44	4.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
223_pEA_EAML Exclusive	GWAS	0.01	1.27	1.15	0.96	3.86
GWAS Exclusive	223_pEA_EAML	0.02	6.10	10.66	8.02	9.45
223_pEA_EAML Exclusive	GWAS Exclusive	0.01	1.29	1.70	0.86	1.20
GWAS Exclusive	223_pEA_EAML Exclusive	0.01	0.69	1.20	0.29	0.07
223_pEA_EAML Exclusive	Overlap	0.00	1.81	-0.18	2.02	4.89
GWAS Exclusive	Overlap	0.09	341.94	250.48	275.85	193.26
Overlap	Exclusives	0.05	27.05	38.25	28.66	40.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
223_pEA_EAML Exclusive	214	210	FOXL2NB;TM9SF1;C17orf113;CHD2
GWAS Exclusive	100	95	D21S2088E;MIR302F;LINC00158;SLC8A1-AS1;PCDH11Y
Overlap	9	9