Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
251_combined_EAML Exclusive	GS_tier1	3.83e-10	3.06e-11	3.42e-10	5.59e-12
GS_tier1 Exclusive	251_combined_EAML	1.62e-01	4.78e-01	1.23e-01	4.61e-01
251_combined_EAML Exclusive	GS_tier1 Exclusive	1.05e-09	1.10e-11	3.39e-09	2.59e-11
GS_tier1 Exclusive	251_combined_EAML Exclusive	1.55e-01	6.15e-01	2.84e-01	2.93e-01
251_combined_EAML Exclusive	Overlap	8.78e-02	7.89e-01	1.15e-01	9.38e-02
GS_tier1 Exclusive	Overlap	8.71e-06	3.66e-05	4.36e-06	1.74e-06
Overlap	Exclusives	5.30e-03	1.32e-04	4.74e-18	2.55e-05



Evaluating how well 251_combined_EAML genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
251_combined_EAML Exclusive	GS_tier1	0.86	3.90	6.92	4.63	6.99
GS_tier1 Exclusive	251_combined_EAML	0.50	1.31	0.69	0.60	0.09
251_combined_EAML Exclusive	GS_tier1 Exclusive	0.87	3.62	7.57	3.93	6.11
GS_tier1 Exclusive	251_combined_EAML Exclusive	0.49	0.88	0.75	0.26	-0.34
251_combined_EAML Exclusive	Overlap	0.81	1.80	1.29	1.70	1.80
GS_tier1 Exclusive	Overlap	0.99	3.13	2.76	3.17	3.06
Overlap	Exclusives	0.57	1.91	5.12	2.28	3.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
251_combined_EAML Exclusive	GS_tier1	0.01	9.98	18.24	11.46	7.50
GS_tier1 Exclusive	251_combined_EAML	0.02	8.66	11.10	8.43	9.40
251_combined_EAML Exclusive	GS_tier1 Exclusive	0.01	7.19	5.75	8.60	11.19
GS_tier1 Exclusive	251_combined_EAML Exclusive	0.02	6.67	8.29	5.18	6.73
251_combined_EAML Exclusive	Overlap	0.00	9.87	12.48	4.34	4.78
GS_tier1 Exclusive	Overlap	0.04	65.19	66.76	31.07	34.23
Overlap	Exclusives	0.04	20.57	28.98	14.06	18.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
251_combined_EAML Exclusive	248	216	yap1;ifi30;cend1;pgf;furin;hnmt;coch;apoe;C17orf113;snap25;cxcl10;cst5;gfap;tcn1;syt1;ahnak;FOXL2NB;sel1l;lag3;cxcl17;fgfbp2;ppy;tnfrsf11a;TM9SF1;gzmh;pdgfc;rtkn2;ceacam1;nefl;CHD2;coq7;tpsd1
GS_tier1 Exclusive	28	27	MS4A
Overlap	3	3