Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
251_combined_EAML Exclusive	GS_tier2	2.10e-02	1.29e-03	2.06e-02	5.27e-05
GS_tier2 Exclusive	251_combined_EAML	3.96e-01	4.49e-01	6.32e-04	5.56e-01
251_combined_EAML Exclusive	GS_tier2 Exclusive	4.64e-02	2.23e-03	1.97e-02	1.63e-04
GS_tier2 Exclusive	251_combined_EAML Exclusive	4.01e-01	3.59e-01	6.83e-04	5.52e-01
251_combined_EAML Exclusive	Overlap	2.97e-01	1.98e-02	2.97e-01	1.98e-02
GS_tier2 Exclusive	Overlap	5.94e-02	1.98e-02	1.98e-02	1.39e-01
Overlap	Exclusives	3.89e-07	1.44e-01	4.40e-43	1.75e-01



Evaluating how well 251_combined_EAML genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
251_combined_EAML Exclusive	GS_tier2	0.67	1.18	2.72	2.02	3.71
GS_tier2 Exclusive	251_combined_EAML	0.51	1.38	0.82	1.21	0.45
251_combined_EAML Exclusive	GS_tier2 Exclusive	0.67	1.19	2.60	1.80	3.55
GS_tier2 Exclusive	251_combined_EAML Exclusive	0.51	1.62	1.16	1.18	0.36
251_combined_EAML Exclusive	Overlap	0.96	0.89	1.28	0.75	1.69
GS_tier2 Exclusive	Overlap	0.94	1.74	2.40	1.17	1.70
Overlap	Exclusives	0.53	5.91	2.40	1.00	1.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
251_combined_EAML Exclusive	GS_tier2	0.01	1.42	3.52	1.42	7.76
GS_tier2 Exclusive	251_combined_EAML	0.01	3.59	3.25	3.51	2.28
251_combined_EAML Exclusive	GS_tier2 Exclusive	0.01	1.21	2.43	1.94	2.98
GS_tier2 Exclusive	251_combined_EAML Exclusive	0.01	4.60	3.19	2.72	3.60
251_combined_EAML Exclusive	Overlap	0.00	0.24	2.07	0.27	6.31
GS_tier2 Exclusive	Overlap	0.00	2.26	8.32	1.44	0.14
Overlap	Exclusives	0.02	3.83	2.55	1.14	1.60

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
251_combined_EAML Exclusive	250	218	snap25;tcn1;ahnak;pdgfc;tpsd1;yap1;sel1l;FOXL2NB;cxcl10;lag3;apoe;hnmt;cend1;TM9SF1;coch;furin;rtkn2;pgf;gzmh;coq7;tnfrsf11a;C17orf113;ceacam1;ppy;cxcl17;nefl;cst5;fgfbp2;gfap;ifi30;syt1;CHD2
GS_tier2 Exclusive	45	42	TNSF12;TNSF13;IGH
Overlap	1	1