Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
251_combined_EAML Exclusive	GWAS	2.62e-01	1.26e-01	6.77e-01	1.47e-03
GWAS Exclusive	251_combined_EAML	3.94e-01	8.07e-01	4.34e-02	5.94e-01
251_combined_EAML Exclusive	GWAS Exclusive	1.36e-01	1.06e-01	5.11e-01	4.06e-03
GWAS Exclusive	251_combined_EAML Exclusive	6.01e-01	8.50e-01	2.39e-01	3.60e-01
251_combined_EAML Exclusive	Overlap	9.27e-01	7.06e-01	7.67e-01	1.30e-01
GWAS Exclusive	Overlap	6.46e-04	1.44e-02	4.13e-04	8.52e-04
Overlap	Exclusives	1.55e-03	4.77e-04	5.80e-19	4.62e-06



Evaluating how well 251_combined_EAML genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
251_combined_EAML Exclusive	GWAS	0.60	0.76	1.36	0.89	3.71
GWAS Exclusive	251_combined_EAML	0.49	1.00	0.39	0.47	-0.15
251_combined_EAML Exclusive	GWAS Exclusive	0.59	0.80	1.17	0.95	3.36
GWAS Exclusive	251_combined_EAML Exclusive	0.48	0.76	0.02	-0.14	-0.76
251_combined_EAML Exclusive	Overlap	0.69	0.32	0.76	1.00	1.89
GWAS Exclusive	Overlap	0.78	2.22	2.03	1.98	3.30
Overlap	Exclusives	0.58	4.22	6.13	3.54	6.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
251_combined_EAML Exclusive	GWAS	0.01	1.18	1.37	1.12	1.72
GWAS Exclusive	251_combined_EAML	0.02	5.63	10.90	7.43	8.01
251_combined_EAML Exclusive	GWAS Exclusive	0.01	1.11	1.82	0.41	1.14
GWAS Exclusive	251_combined_EAML Exclusive	0.01	1.63	1.08	0.56	0.40
251_combined_EAML Exclusive	Overlap	0.00	1.83	-0.19	2.88	2.95
GWAS Exclusive	Overlap	0.09	271.61	247.54	229.61	294.34
Overlap	Exclusives	0.05	31.03	39.44	23.95	48.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
251_combined_EAML Exclusive	242	210	hnmt;fgfbp2;ppy;coch;pgf;sel1l;coq7;tpsd1;CHD2;apoe;cxcl17;syt1;cst5;nefl;tcn1;FOXL2NB;snap25;ifi30;gzmh;yap1;gfap;TM9SF1;tnfrsf11a;rtkn2;ahnak;pdgfc;C17orf113;lag3;furin;cxcl10;cend1;ceacam1
GWAS Exclusive	100	95	D21S2088E;MIR302F;PCDH11Y;SLC8A1-AS1;LINC00158
Overlap	9	9