Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
35_NPX_EAML Exclusive	tier1_GS	2.21e-02	2.34e-02	8.34e-03	6.16e-04
tier1_GS Exclusive	35_NPX_EAML	1.07e-02	1.69e-03	9.27e-04	1.80e-04
35_NPX_EAML Exclusive	tier1_GS Exclusive	2.99e-02	1.44e-02	1.55e-02	1.30e-03
tier1_GS Exclusive	35_NPX_EAML Exclusive	2.07e-02	9.68e-04	1.26e-03	5.35e-04
35_NPX_EAML Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	7.92e-02
tier1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.36e-03	2.88e-15	2.29e-45	3.87e-22



Evaluating how well 35_NPX_EAML genes are linked to tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_NPX_EAML Exclusive	tier1_GS	0.72	3.73	3.08	2.15	4.31
tier1_GS Exclusive	35_NPX_EAML	0.72	1.94	3.73	2.20	4.73
35_NPX_EAML Exclusive	tier1_GS Exclusive	0.72	3.72	3.39	1.38	3.91
tier1_GS Exclusive	35_NPX_EAML Exclusive	0.72	1.94	4.12	2.14	4.15
35_NPX_EAML Exclusive	Overlap	0.97	1.32	-83965812100748.67	1.31	1.62
tier1_GS Exclusive	Overlap	1.00	1.24	inf	1.50	1.64
Overlap	Exclusives	0.86	727767521289878.00	9.22	2.58	9.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_NPX_EAML Exclusive	tier1_GS	0.00	7.04	0.18	2.46	3.46
tier1_GS Exclusive	35_NPX_EAML	0.00	2.75	6.29	1.87	0.85
35_NPX_EAML Exclusive	tier1_GS Exclusive	0.00	4.71	0.62	0.68	3.67
tier1_GS Exclusive	35_NPX_EAML Exclusive	0.00	1.78	6.84	2.77	4.52
35_NPX_EAML Exclusive	Overlap	0.00	2.21	-inf	1.34	3.00
tier1_GS Exclusive	Overlap	0.02	22.46	151272923003761312.00	65.98	13.23
Overlap	Exclusives	0.02	8361924070514225.00	30.77	6.08	28.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
35_NPX_EAML Exclusive	34	34	
tier1_GS Exclusive	30	29	MS4A
Overlap	1	1