Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
35_NPX_EAML	Ismael_GS	4.29e-10	1.39e-12	2.92e-13	4.33e-12
Ismael_GS	35_NPX_EAML	3.69e-05	4.07e-05	1.90e-08	2.29e-09



Evaluating how well 35_NPX_EAML genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_NPX_EAML	Ismael_GS	0.94	2.88	7.03	3.17	5.69
Ismael_GS	35_NPX_EAML	0.79	4.45	6.64	3.00	5.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_NPX_EAML	Ismael_GS	0.01	3.56	26.01	6.13	11.99
Ismael_GS	35_NPX_EAML	0.01	4.97	7.61	7.10	1.96

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
35_NPX_EAML	35	35	
Ismael_GS	14	14