Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
35_NPX_EAML Exclusive	GWAS	7.43e-03	8.04e-03	1.04e-03	4.82e-05
GWAS Exclusive	35_NPX_EAML	2.97e-03	2.43e-04	8.59e-06	2.94e-07
35_NPX_EAML Exclusive	GWAS Exclusive	7.62e-03	6.15e-03	1.73e-03	3.51e-05
GWAS Exclusive	35_NPX_EAML Exclusive	1.62e-03	1.92e-04	1.05e-05	6.46e-06
35_NPX_EAML Exclusive	Overlap	1.98e-02	1.98e-02	3.96e-02	1.19e-01
GWAS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	8.07e-04	1.55e-13	3.70e-59	5.69e-20



Evaluating how well 35_NPX_EAML genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_NPX_EAML Exclusive	GWAS	0.65	2.98	3.54	2.47	4.97
GWAS Exclusive	35_NPX_EAML	0.75	3.11	3.97	3.30	5.64
35_NPX_EAML Exclusive	GWAS Exclusive	0.65	2.94	3.56	2.56	5.07
GWAS Exclusive	35_NPX_EAML Exclusive	0.74	3.38	4.11	3.00	5.12
35_NPX_EAML Exclusive	Overlap	0.97	1.26	-83965812100748.67	1.33	1.51
GWAS Exclusive	Overlap	1.00	1.19	96906977428865.00	1.18	1.68
Overlap	Exclusives	0.74	228770747050122.00	10.26	3.00	9.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
35_NPX_EAML Exclusive	GWAS	0.01	6.01	5.34	3.77	6.53
GWAS Exclusive	35_NPX_EAML	0.01	7.08	9.13	8.58	3.47
35_NPX_EAML Exclusive	GWAS Exclusive	0.01	6.06	5.95	4.19	4.08
GWAS Exclusive	35_NPX_EAML Exclusive	0.01	4.86	7.12	5.07	6.34
35_NPX_EAML Exclusive	Overlap	0.00	1.45	-inf	1.51	1.67
GWAS Exclusive	Overlap	0.04	41.42	inf	60.42	181.25
Overlap	Exclusives	0.03	2447505108271349.50	29.19	7.14	13.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
35_NPX_EAML Exclusive	34	34	
GWAS Exclusive	108	103	LINC00158;PCDH11Y;D21S2088E;MIR302F;SLC8A1-AS1
Overlap	1	1