Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Regulome_R4_selected_Male_3 Exclusive	Tier1_31	3.46e-04	8.20e-04	5.30e-05	2.15e-05
Tier1_31 Exclusive	Regulome_R4_selected_Male_3	2.16e-01	2.66e-01	4.25e-01	1.24e-01
Regulome_R4_selected_Male_3 Exclusive	Tier1_31 Exclusive	2.23e-04	2.97e-04	1.18e-04	1.86e-05
Tier1_31 Exclusive	Regulome_R4_selected_Male_3 Exclusive	2.53e-01	3.82e-01	4.33e-01	2.26e-01
Regulome_R4_selected_Male_3 Exclusive	Overlap	5.17e-01	5.17e-01	5.17e-01	1.57e-01
Tier1_31 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	7.54e-03	1.07e-04	4.36e-22	1.81e-07



Evaluating how well Regulome_R4_selected_Male_3 genes are linked to Tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected_Male_3 Exclusive	Tier1_31	0.79	3.21	5.42	3.26	5.18
Tier1_31 Exclusive	Regulome_R4_selected_Male_3	0.55	0.71	1.03	0.70	1.65
Regulome_R4_selected_Male_3 Exclusive	Tier1_31 Exclusive	0.78	3.03	4.65	2.84	6.03
Tier1_31 Exclusive	Regulome_R4_selected_Male_3 Exclusive	0.54	0.64	0.73	0.48	1.45
Regulome_R4_selected_Male_3 Exclusive	Overlap	0.83	1.28	0.59	1.05	1.79
Tier1_31 Exclusive	Overlap	1.00	2.62	1.70	2.09	2.76
Overlap	Exclusives	0.63	4.69	5.43	2.79	6.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected_Male_3 Exclusive	Tier1_31	0.01	5.44	1.93	6.80	1.20
Tier1_31 Exclusive	Regulome_R4_selected_Male_3	0.01	7.51	4.28	5.23	6.74
Regulome_R4_selected_Male_3 Exclusive	Tier1_31 Exclusive	0.00	6.07	1.56	3.01	6.47
Tier1_31 Exclusive	Regulome_R4_selected_Male_3 Exclusive	0.01	3.98	4.08	3.56	2.29
Regulome_R4_selected_Male_3 Exclusive	Overlap	0.00	6.87	10.91	4.98	7.48
Tier1_31 Exclusive	Overlap	0.02	54.69	40.54	36.63	59.37
Overlap	Exclusives	0.02	12.87	12.32	10.09	9.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Regulome_R4_selected_Male_3 Exclusive	111	110	PRAMEF15
Tier1_31 Exclusive	29	28	MS4A
Overlap	2	2