Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Regulome_R4_selected_Male_3	Tier2_gs	7.06e-01	6.76e-01	7.95e-01	2.54e-01
Tier2_gs	Regulome_R4_selected_Male_3	5.69e-01	7.61e-01	3.71e-02	2.78e-01



Evaluating how well Regulome_R4_selected_Male_3 genes are linked to Tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected_Male_3	Tier2_gs	0.59	-0.43	-0.28	-0.18	1.98
Tier2_gs	Regulome_R4_selected_Male_3	0.54	0.05	0.75	0.34	1.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected_Male_3	Tier2_gs	0.00	1.01	0.94	1.80	4.62
Tier2_gs	Regulome_R4_selected_Male_3	0.01	-0.13	-0.11	0.06	0.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Regulome_R4_selected_Male_3	114	112	Gene_name;PRAMEF15
Tier2_gs	46	43	TNSF12;TNSF13;IGH