Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Regulome_R4_selected_Male_3	Ismael_14_AD	8.49e-01	7.98e-01	8.42e-01	8.30e-02
Ismael_14_AD	Regulome_R4_selected_Male_3	6.58e-01	4.98e-01	2.04e-04	1.00e-01



Evaluating how well Regulome_R4_selected_Male_3 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected_Male_3	Ismael_14_AD	0.67	-0.06	0.68	0.11	2.24
Ismael_14_AD	Regulome_R4_selected_Male_3	0.56	2.52	1.26	0.89	2.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected_Male_3	Ismael_14_AD	0.00	0.52	1.04	1.76	5.33
Ismael_14_AD	Regulome_R4_selected_Male_3	0.01	2.36	0.12	0.64	0.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Regulome_R4_selected_Male_3	113	112	PRAMEF15
Ismael_14_AD	14	14