Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Regulome_R4_selected_Female_3 Exclusive	TIER1_GS	5.91e-09	1.84e-07	1.17e-08	7.04e-11
TIER1_GS Exclusive	Regulome_R4_selected_Female_3	1.15e-01	4.60e-02	1.42e-02	1.29e-02
Regulome_R4_selected_Female_3 Exclusive	TIER1_GS Exclusive	6.99e-09	2.52e-07	1.85e-08	8.46e-11
TIER1_GS Exclusive	Regulome_R4_selected_Female_3 Exclusive	2.24e-01	6.38e-02	3.97e-02	1.99e-02
Regulome_R4_selected_Female_3 Exclusive	Overlap	6.10e-01	4.68e-01	6.10e-01	1.69e-01
TIER1_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	4.01e-02	2.05e-03	1.28e-20	7.30e-06



Evaluating how well Regulome_R4_selected_Female_3 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected_Female_3 Exclusive	TIER1_GS	0.87	4.85	7.52	4.60	6.45
TIER1_GS Exclusive	Regulome_R4_selected_Female_3	0.60	3.04	3.36	3.20	3.73
Regulome_R4_selected_Female_3 Exclusive	TIER1_GS Exclusive	0.87	5.26	7.41	4.36	6.16
TIER1_GS Exclusive	Regulome_R4_selected_Female_3 Exclusive	0.59	3.00	2.90	2.65	3.43
Regulome_R4_selected_Female_3 Exclusive	Overlap	0.85	1.22	0.77	1.07	1.70
TIER1_GS Exclusive	Overlap	1.00	2.67	1.77	2.32	2.32
Overlap	Exclusives	0.64	2.22	5.02	2.55	5.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected_Female_3 Exclusive	TIER1_GS	0.01	17.15	25.58	9.90	13.35
TIER1_GS Exclusive	Regulome_R4_selected_Female_3	0.01	10.57	12.33	12.55	5.61
Regulome_R4_selected_Female_3 Exclusive	TIER1_GS Exclusive	0.01	23.55	6.57	15.51	19.17
TIER1_GS Exclusive	Regulome_R4_selected_Female_3 Exclusive	0.01	7.37	8.30	7.72	8.02
Regulome_R4_selected_Female_3 Exclusive	Overlap	0.00	0.61	-1.36	1.94	3.20
TIER1_GS Exclusive	Overlap	0.02	35.98	42.25	43.98	76.81
Overlap	Exclusives	0.02	6.82	15.59	9.61	19.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Regulome_R4_selected_Female_3 Exclusive	104	99	LINC02210-CRHR1;ZNF511-PRAP1;GSTT4;FAM205C;AC005779.2
TIER1_GS Exclusive	29	28	MS4A
Overlap	2	2