Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Regulome_R4_selected_Female_3 Exclusive Ismael_14_AD 6.38e-01 8.07e-02 2.61e-01 1.38e-02 Ismael_14_AD Exclusive Regulome_R4_selected_Female_3 7.08e-01 3.08e-01 2.90e-06 6.64e-02 Regulome_R4_selected_Female_3 Exclusive Ismael_14_AD Exclusive 8.44e-01 1.93e-01 1.63e-01 2.58e-02 Ismael_14_AD Exclusive Regulome_R4_selected_Female_3 Exclusive 8.70e-01 2.61e-01 3.60e-06 6.40e-02 Regulome_R4_selected_Female_3 Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Ismael_14_AD Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 1.85e-07 9.64e-04 2.00e-26 1.57e-05 Evaluating how well Regulome_R4_selected_Female_3 genes are linked to Ismael_14_AD genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Regulome_R4_selected_Female_3 Exclusive Ismael_14_AD 0.76 0.79 2.49 1.02 3.94 Ismael_14_AD Exclusive Regulome_R4_selected_Female_3 0.57 2.40 1.94 1.90 2.55 Regulome_R4_selected_Female_3 Exclusive Ismael_14_AD Exclusive 0.74 0.66 2.32 1.31 3.08 Ismael_14_AD Exclusive Regulome_R4_selected_Female_3 Exclusive 0.57 2.20 1.65 1.81 2.43 Regulome_R4_selected_Female_3 Exclusive Overlap 1.00 1.45 1044045000140298.50 1.42 1.92 Ismael_14_AD Exclusive Overlap 1.00 1.79 1796314181429203.00 2.38 1.69 Overlap Exclusives 0.63 2641770227486350.00 4.61 2.31 4.71 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Regulome_R4_selected_Female_3 Exclusive Ismael_14_AD 0.00 0.95 6.40 0.99 5.49 Ismael_14_AD Exclusive Regulome_R4_selected_Female_3 0.01 2.78 1.13 2.11 1.10 Regulome_R4_selected_Female_3 Exclusive Ismael_14_AD Exclusive 0.00 -0.11 2.80 0.73 1.07 Ismael_14_AD Exclusive Regulome_R4_selected_Female_3 Exclusive 0.01 1.91 0.58 1.22 1.13 Regulome_R4_selected_Female_3 Exclusive Overlap 0.01 26.89 586899398150088192.00 28.14 113.53 Ismael_14_AD Exclusive Overlap 0.01 19.45 inf 52.39 10.94 Overlap Exclusives 0.02 4394560557440418.50 18.41 7.34 6.98 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Regulome_R4_selected_Female_3 Exclusive 105 100 AC005779.2;ZNF511-PRAP1;GSTT4;LINC02210-CRHR1;FAM205C Ismael_14_AD Exclusive 13 13 Overlap 1 1