Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Regulome_R4_selected2	Ismael_14_AD	9.46e-01	7.64e-01	5.35e-01	6.26e-02
Ismael_14_AD	Regulome_R4_selected2	6.40e-01	6.94e-02	1.02e-09	8.66e-03



Evaluating how well Regulome_R4_selected2 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected2	Ismael_14_AD	0.67	-0.06	0.14	0.14	2.37
Ismael_14_AD	Regulome_R4_selected2	0.58	3.41	2.61	3.02	3.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected2	Ismael_14_AD	0.01	3.04	8.88	2.83	2.16
Ismael_14_AD	Regulome_R4_selected2	0.01	1.71	1.15	1.78	2.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Regulome_R4_selected2	184	177	TNFSF12-TNFSF13;TAF11L13;TMEM191C;AL451062.3;AC005779.2;LINC02210-CRHR1;PRAMEF15
Ismael_14_AD	14	14