Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Binary_EA_as1 Exclusive	Tier2_gs	7.72e-02	5.83e-03	1.97e-02	4.39e-04
Tier2_gs Exclusive	Binary_EA_as1	4.14e-02	1.19e-01	1.68e-04	2.91e-02
Binary_EA_as1 Exclusive	Tier2_gs Exclusive	3.64e-02	3.48e-03	1.30e-02	4.62e-04
Tier2_gs Exclusive	Binary_EA_as1 Exclusive	6.49e-02	1.86e-01	3.79e-04	3.21e-02
Binary_EA_as1 Exclusive	Overlap	3.56e-01	6.93e-01	6.14e-01	8.51e-01
Tier2_gs Exclusive	Overlap	3.96e-02	1.98e-02	3.96e-02	5.94e-02
Overlap	Exclusives	6.48e-03	2.75e-01	8.27e-01	1.93e-02



Evaluating how well Binary_EA_as1 genes are linked to Tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Binary_EA_as1 Exclusive	Tier2_gs	0.70	2.80	3.66	2.70	4.81
Tier2_gs Exclusive	Binary_EA_as1	0.57	3.72	2.32	2.35	2.98
Binary_EA_as1 Exclusive	Tier2_gs Exclusive	0.70	2.81	4.31	2.96	4.84
Tier2_gs Exclusive	Binary_EA_as1 Exclusive	0.57	3.29	2.16	2.25	2.73
Binary_EA_as1 Exclusive	Overlap	0.54	0.78	0.40	0.44	0.16
Tier2_gs Exclusive	Overlap	0.99	2.42	2.32	1.97	1.65
Overlap	Exclusives	0.58	1.15	2.14	1.14	3.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Binary_EA_as1 Exclusive	Tier2_gs	0.01	7.37	12.90	6.88	13.83
Tier2_gs Exclusive	Binary_EA_as1	0.02	24.38	19.24	12.54	18.84
Binary_EA_as1 Exclusive	Tier2_gs Exclusive	0.01	8.00	16.34	7.81	10.97
Tier2_gs Exclusive	Binary_EA_as1 Exclusive	0.02	22.63	19.88	19.27	21.13
Binary_EA_as1 Exclusive	Overlap	0.00	-0.12	-0.21	-0.12	-0.16
Tier2_gs Exclusive	Overlap	0.00	1.24	10.85	2.35	0.60
Overlap	Exclusives	0.01	2.01	4.98	2.53	7.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Binary_EA_as1 Exclusive	129	124	TAF11L13;CCDC187;DUXB;CHURC1-FNTB;TNFSF12-TNFSF13
Tier2_gs Exclusive	45	42	TNSF12;IGH;TNSF13
Overlap	1	1