Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Binary_EA_as1 Exclusive	Ismael_14_AD	7.32e-02	2.81e-02	1.73e-02	4.23e-04
Ismael_14_AD Exclusive	Binary_EA_as1	5.38e-01	2.57e-01	4.65e-07	4.46e-02
Binary_EA_as1 Exclusive	Ismael_14_AD Exclusive	4.73e-02	1.33e-02	8.30e-03	1.83e-04
Ismael_14_AD Exclusive	Binary_EA_as1 Exclusive	4.09e-01	4.06e-01	3.34e-06	1.00e-01
Binary_EA_as1 Exclusive	Overlap	3.17e-01	8.12e-01	4.75e-01	8.91e-01
Ismael_14_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.24e-03	5.06e-02	1.15e-01	4.19e-03



Evaluating how well Binary_EA_as1 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Binary_EA_as1 Exclusive	Ismael_14_AD	0.82	2.11	3.16	2.06	4.55
Ismael_14_AD Exclusive	Binary_EA_as1	0.56	3.14	1.98	1.63	2.64
Binary_EA_as1 Exclusive	Ismael_14_AD Exclusive	0.84	2.25	3.73	2.06	4.41
Ismael_14_AD Exclusive	Binary_EA_as1 Exclusive	0.56	2.67	1.70	1.20	2.08
Binary_EA_as1 Exclusive	Overlap	0.54	1.25	0.28	0.63	0.16
Ismael_14_AD Exclusive	Overlap	1.00	4.38	2.26	2.48	1.52
Overlap	Exclusives	0.58	1.07	2.31	0.97	3.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Binary_EA_as1 Exclusive	Ismael_14_AD	0.01	4.64	7.66	6.56	7.22
Ismael_14_AD Exclusive	Binary_EA_as1	0.01	9.22	8.07	7.32	10.05
Binary_EA_as1 Exclusive	Ismael_14_AD Exclusive	0.01	8.29	9.72	7.63	2.48
Ismael_14_AD Exclusive	Binary_EA_as1 Exclusive	0.01	4.13	3.86	2.78	3.75
Binary_EA_as1 Exclusive	Overlap	0.00	0.15	-0.16	-0.12	-0.21
Ismael_14_AD Exclusive	Overlap	0.25	13723.28	1117.50	91.85	1198.56
Overlap	Exclusives	0.02	9.72	23.07	6.57	12.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Binary_EA_as1 Exclusive	129	124	DUXB;CHURC1-FNTB;CCDC187;TAF11L13;TNFSF12-TNFSF13
Ismael_14_AD Exclusive	13	13	
Overlap	1	1