Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_R4	Ismael_14_AD	5.73e-02	1.71e-01	1.12e-01	1.54e-03
Ismael_14_AD	Sigma_EA_R4	3.26e-01	2.54e-02	7.27e-07	2.82e-02



Evaluating how well Sigma_EA_R4 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R4	Ismael_14_AD	0.80	2.27	2.74	1.66	4.11
Ismael_14_AD	Sigma_EA_R4	0.56	4.10	2.77	2.46	2.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_R4	Ismael_14_AD	0.01	8.20	11.11	5.17	12.54
Ismael_14_AD	Sigma_EA_R4	0.01	3.93	3.63	2.91	4.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_R4	116	113	CHURC1-FNTB;EDDM13;10-Mar
Ismael_14_AD	14	14