Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Binary_regulome_as1 Exclusive	TIER1_GS	4.89e-04	1.62e-04	7.93e-05	2.62e-06
TIER1_GS Exclusive	Binary_regulome_as1	3.13e-01	4.27e-01	1.22e-01	9.10e-02
Binary_regulome_as1 Exclusive	TIER1_GS Exclusive	4.91e-03	1.30e-03	1.32e-03	1.62e-04
TIER1_GS Exclusive	Binary_regulome_as1 Exclusive	5.64e-01	5.60e-01	1.41e-01	3.00e-01
Binary_regulome_as1 Exclusive	Overlap	3.44e-01	3.00e-01	1.27e-01	2.95e-03
TIER1_GS Exclusive	Overlap	9.59e-09	1.02e-05	4.17e-10	1.96e-07
Overlap	Exclusives	2.37e-03	4.44e-03	5.95e-20	1.05e-03



Evaluating how well Binary_regulome_as1 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Binary_regulome_as1 Exclusive	TIER1_GS	0.78	3.70	5.01	3.15	4.95
TIER1_GS Exclusive	Binary_regulome_as1	0.56	1.99	1.73	1.85	2.50
Binary_regulome_as1 Exclusive	TIER1_GS Exclusive	0.76	2.91	4.49	2.74	4.61
TIER1_GS Exclusive	Binary_regulome_as1 Exclusive	0.54	1.29	1.39	1.51	1.74
Binary_regulome_as1 Exclusive	Overlap	0.87	1.40	1.64	1.96	2.81
TIER1_GS Exclusive	Overlap	0.99	3.32	3.88	3.40	3.54
Overlap	Exclusives	0.59	3.35	3.80	2.78	4.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Binary_regulome_as1 Exclusive	TIER1_GS	0.01	12.81	12.97	10.91	18.24
TIER1_GS Exclusive	Binary_regulome_as1	0.02	11.63	6.32	6.47	6.64
Binary_regulome_as1 Exclusive	TIER1_GS Exclusive	0.01	9.04	16.14	8.83	11.23
TIER1_GS Exclusive	Binary_regulome_as1 Exclusive	0.01	4.44	3.93	4.30	2.12
Binary_regulome_as1 Exclusive	Overlap	0.00	6.00	3.12	8.14	13.23
TIER1_GS Exclusive	Overlap	0.04	128.22	47.17	158.42	93.85
Overlap	Exclusives	0.06	45.35	49.89	37.89	47.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Binary_regulome_as1 Exclusive	177	171	TMEM191C;AC005779.2;TNFSF12-TNFSF13;OOSP3;PRAMEF15;TAF11L13
TIER1_GS Exclusive	26	25	MS4A
Overlap	5	5