Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Binary_regulome_as1	Tier2_gs	7.88e-01	1.68e-01	3.62e-01	1.42e-02
Tier2_gs	Binary_regulome_as1	4.19e-01	7.49e-01	1.16e-03	2.20e-01



Evaluating how well Binary_regulome_as1 genes are linked to Tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Binary_regulome_as1	Tier2_gs	0.64	0.60	1.51	1.04	4.00
Tier2_gs	Binary_regulome_as1	0.54	1.16	0.61	0.79	1.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Binary_regulome_as1	Tier2_gs	0.01	0.61	4.40	1.98	4.31
Tier2_gs	Binary_regulome_as1	0.01	0.96	0.53	1.17	0.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Binary_regulome_as1	182	176	PRAMEF15;TAF11L13;OOSP3;TMEM191C;TNFSF12-TNFSF13;AC005779.2
Tier2_gs	46	43	TNSF13;IGH;TNSF12