Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Binary_regulome_as1	Ismael_14_AD	7.11e-01	8.22e-01	4.88e-01	8.07e-02
Ismael_14_AD	Binary_regulome_as1	3.12e-01	9.63e-02	5.87e-10	1.98e-02



Evaluating how well Binary_regulome_as1 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Binary_regulome_as1	Ismael_14_AD	0.66	-0.01	-0.23	-0.01	2.04
Ismael_14_AD	Binary_regulome_as1	0.56	2.75	2.75	2.64	2.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Binary_regulome_as1	Ismael_14_AD	0.00	1.55	3.04	2.35	9.01
Ismael_14_AD	Binary_regulome_as1	0.01	1.41	1.21	1.27	1.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Binary_regulome_as1	182	176	TAF11L13;PRAMEF15;TMEM191C;TNFSF12-TNFSF13;OOSP3;AC005779.2
Ismael_14_AD	14	14