Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Regulome_R4_selected2_Female_3 Exclusive	Regulome_R4_selected2_Male_3	5.74e-01	6.89e-01	2.83e-01	7.20e-02
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_Female_3	4.52e-01	6.08e-01	3.50e-01	4.95e-01
Regulome_R4_selected2_Female_3 Exclusive	Regulome_R4_selected2_Male_3 Exclusive	7.95e-01	8.33e-01	4.10e-01	2.18e-01
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_Female_3 Exclusive	5.46e-01	5.84e-01	2.61e-01	5.28e-01
Regulome_R4_selected2_Female_3 Exclusive	Overlap	4.04e-01	4.48e-01	3.66e-01	5.95e-02
Regulome_R4_selected2_Male_3 Exclusive	Overlap	6.89e-01	3.03e-01	6.72e-01	9.94e-01
Overlap	Exclusives	7.45e-02	5.41e-01	1.40e-07	1.95e-02



Evaluating how well Regulome_R4_selected2_Female_3 genes are linked to Regulome_R4_selected2_Male_3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected2_Female_3 Exclusive	Regulome_R4_selected2_Male_3	0.55	1.31	1.14	0.98	2.45
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_Female_3	0.52	0.06	-0.00	-0.11	0.80
Regulome_R4_selected2_Female_3 Exclusive	Regulome_R4_selected2_Male_3 Exclusive	0.54	0.88	0.73	0.74	1.52
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_Female_3 Exclusive	0.52	0.42	0.35	0.29	0.78
Regulome_R4_selected2_Female_3 Exclusive	Overlap	0.70	1.64	1.61	1.48	2.29
Regulome_R4_selected2_Male_3 Exclusive	Overlap	0.50	-1.38	-1.64	-1.27	0.09
Overlap	Exclusives	0.53	0.01	0.58	0.38	1.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected2_Female_3 Exclusive	Regulome_R4_selected2_Male_3	0.01	0.21	0.01	-0.05	0.58
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_Female_3	0.01	0.19	-0.02	-0.08	0.72
Regulome_R4_selected2_Female_3 Exclusive	Regulome_R4_selected2_Male_3 Exclusive	0.01	0.49	0.11	-0.11	0.40
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_Female_3 Exclusive	0.01	0.47	0.46	0.42	0.74
Regulome_R4_selected2_Female_3 Exclusive	Overlap	0.00	0.16	-1.07	0.25	1.39
Regulome_R4_selected2_Male_3 Exclusive	Overlap	0.00	-0.34	-1.23	-0.82	-0.25
Overlap	Exclusives	0.01	-0.67	-0.09	-0.27	0.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Regulome_R4_selected2_Female_3 Exclusive	97	92	LINC02210-CRHR1;AC005779.2;GSTT4;FAM205C;ZNF511-PRAP1
Regulome_R4_selected2_Male_3 Exclusive	104	103	PRAMEF15
Overlap	9	9