Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Regulome_R4_selected2_combined Exclusive	Regulome_R4_selected2_Male_3	1.96e-01	1.36e-01	3.49e-02	2.67e-02
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_combined	2.18e-01	3.97e-01	8.66e-02	2.17e-01
Regulome_R4_selected2_combined Exclusive	Regulome_R4_selected2_Male_3 Exclusive	8.86e-01	6.86e-01	4.91e-01	2.62e-01
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_combined Exclusive	4.85e-01	7.39e-01	3.62e-01	6.72e-01
Regulome_R4_selected2_combined Exclusive	Overlap	6.10e-02	5.11e-02	2.25e-02	5.21e-03
Regulome_R4_selected2_Male_3 Exclusive	Overlap	2.14e-01	2.00e-01	5.77e-02	3.41e-02
Overlap	Exclusives	6.62e-02	3.67e-02	1.86e-04	1.32e-02



Evaluating how well Regulome_R4_selected2_combined genes are linked to Regulome_R4_selected2_Male_3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected2_combined Exclusive	Regulome_R4_selected2_Male_3	0.57	1.50	1.73	1.81	2.42
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_combined	0.53	0.71	0.93	0.65	1.34
Regulome_R4_selected2_combined Exclusive	Regulome_R4_selected2_Male_3 Exclusive	0.54	0.50	0.99	0.49	1.15
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_combined Exclusive	0.51	-0.07	0.02	-0.26	0.48
Regulome_R4_selected2_combined Exclusive	Overlap	0.63	1.98	2.20	2.10	2.54
Regulome_R4_selected2_Male_3 Exclusive	Overlap	0.63	2.04	1.95	2.30	2.66
Overlap	Exclusives	0.56	2.56	2.95	2.25	2.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Regulome_R4_selected2_combined Exclusive	Regulome_R4_selected2_Male_3	0.01	1.18	1.30	1.15	2.19
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_combined	0.01	1.06	0.44	0.88	0.87
Regulome_R4_selected2_combined Exclusive	Regulome_R4_selected2_Male_3 Exclusive	0.00	-0.33	0.12	-0.33	0.13
Regulome_R4_selected2_Male_3 Exclusive	Regulome_R4_selected2_combined Exclusive	0.01	0.35	0.04	0.16	0.17
Regulome_R4_selected2_combined Exclusive	Overlap	0.00	3.07	2.88	4.39	0.46
Regulome_R4_selected2_Male_3 Exclusive	Overlap	0.00	1.36	1.76	0.40	0.12
Overlap	Exclusives	0.02	2.66	4.55	3.38	3.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Regulome_R4_selected2_combined Exclusive	149	143	TAF11L13;AC005779.2;LINC02210-CRHR1;TNFSF12-TNFSF13;TMEM191C;AL451062.3
Regulome_R4_selected2_Male_3 Exclusive	78	78	
Overlap	35	34	PRAMEF15