Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) top_122_SKATO Exclusive GS_tier1 5.00e-01 6.23e-01 5.38e-01 2.14e-02 GS_tier1 Exclusive top_122_SKATO 3.80e-04 3.35e-01 4.32e-02 1.01e-01 top_122_SKATO Exclusive GS_tier1 Exclusive 6.87e-01 5.45e-01 6.71e-01 2.26e-02 GS_tier1 Exclusive top_122_SKATO Exclusive 4.57e-04 3.40e-01 9.87e-02 6.96e-02 top_122_SKATO Exclusive Overlap 7.08e-01 8.62e-01 8.51e-01 9.96e-01 GS_tier1 Exclusive Overlap 9.85e-05 9.85e-05 9.85e-05 9.85e-05 Overlap Exclusives 2.77e-04 4.76e-04 7.44e-09 3.93e-06 Evaluating how well top_122_SKATO genes are linked to GS_tier1 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) top_122_SKATO Exclusive GS_tier1 0.60 -0.01 0.05 0.18 2.00 GS_tier1 Exclusive top_122_SKATO 0.52 -0.64 -0.59 0.20 0.49 top_122_SKATO Exclusive GS_tier1 Exclusive 0.60 0.06 0.11 -0.05 1.87 GS_tier1 Exclusive top_122_SKATO Exclusive 0.51 -0.88 -0.75 -0.09 0.49 top_122_SKATO Exclusive Overlap 0.51 -0.66 -0.40 -0.48 0.09 GS_tier1 Exclusive Overlap 1.00 2.65 2.51 2.54 2.22 Overlap Exclusives 0.63 2.01 4.54 3.02 5.67 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) top_122_SKATO Exclusive GS_tier1 0.00 0.21 0.08 0.15 0.74 GS_tier1 Exclusive top_122_SKATO 0.01 3.32 5.68 5.29 2.75 top_122_SKATO Exclusive GS_tier1 Exclusive 0.00 0.36 -0.06 0.14 0.07 GS_tier1 Exclusive top_122_SKATO Exclusive 0.01 -0.11 0.35 0.36 0.56 top_122_SKATO Exclusive Overlap 0.00 -0.54 -0.33 -0.43 -0.15 GS_tier1 Exclusive Overlap 0.12 443.27 134.11 285.09 353.41 Overlap Exclusives 0.05 23.72 63.10 36.25 74.30 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes top_122_SKATO Exclusive 120 114 RP11-385D13.1;CTD-2611O12.2;CTC-512J12.6;AGAP9;AC008734.2;AC008734.1 GS_tier1 Exclusive 29 28 MS4A Overlap 2 2