Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
top_122_SKATO Exclusive	GS_tier1	5.00e-01	6.23e-01	5.38e-01	2.14e-02
GS_tier1 Exclusive	top_122_SKATO	3.80e-04	3.35e-01	4.32e-02	1.01e-01
top_122_SKATO Exclusive	GS_tier1 Exclusive	6.87e-01	5.45e-01	6.71e-01	2.26e-02
GS_tier1 Exclusive	top_122_SKATO Exclusive	4.57e-04	3.40e-01	9.87e-02	6.96e-02
top_122_SKATO Exclusive	Overlap	7.08e-01	8.62e-01	8.51e-01	9.96e-01
GS_tier1 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	2.77e-04	4.76e-04	7.44e-09	3.93e-06



Evaluating how well top_122_SKATO genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_122_SKATO Exclusive	GS_tier1	0.60	-0.01	0.05	0.18	2.00
GS_tier1 Exclusive	top_122_SKATO	0.52	-0.64	-0.59	0.20	0.49
top_122_SKATO Exclusive	GS_tier1 Exclusive	0.60	0.06	0.11	-0.05	1.87
GS_tier1 Exclusive	top_122_SKATO Exclusive	0.51	-0.88	-0.75	-0.09	0.49
top_122_SKATO Exclusive	Overlap	0.51	-0.66	-0.40	-0.48	0.09
GS_tier1 Exclusive	Overlap	1.00	2.65	2.51	2.54	2.22
Overlap	Exclusives	0.63	2.01	4.54	3.02	5.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
top_122_SKATO Exclusive	GS_tier1	0.00	0.21	0.08	0.15	0.74
GS_tier1 Exclusive	top_122_SKATO	0.01	3.32	5.68	5.29	2.75
top_122_SKATO Exclusive	GS_tier1 Exclusive	0.00	0.36	-0.06	0.14	0.07
GS_tier1 Exclusive	top_122_SKATO Exclusive	0.01	-0.11	0.35	0.36	0.56
top_122_SKATO Exclusive	Overlap	0.00	-0.54	-0.33	-0.43	-0.15
GS_tier1 Exclusive	Overlap	0.12	443.27	134.11	285.09	353.41
Overlap	Exclusives	0.05	23.72	63.10	36.25	74.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
top_122_SKATO Exclusive	120	114	RP11-385D13.1;CTD-2611O12.2;CTC-512J12.6;AGAP9;AC008734.2;AC008734.1
GS_tier1 Exclusive	29	28	MS4A
Overlap	2	2