Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB470K_EAML_Union Exclusive	AoU245K_EAML_Union	5.29e-01	7.59e-01	1.48e-01	2.99e-02
AoU245K_EAML_Union Exclusive	UKB470K_EAML_Union	1.33e-01	5.14e-01	5.03e-03	4.36e-01
UKB470K_EAML_Union Exclusive	AoU245K_EAML_Union Exclusive	6.29e-01	5.64e-01	1.40e-01	1.19e-02
AoU245K_EAML_Union Exclusive	UKB470K_EAML_Union Exclusive	1.17e-01	5.25e-01	3.29e-03	4.07e-01
UKB470K_EAML_Union Exclusive	Overlap	1.61e-01	1.20e-01	1.06e-01	1.07e-02
AoU245K_EAML_Union Exclusive	Overlap	4.27e-01	2.78e-01	3.43e-01	4.96e-01
Overlap	Exclusives	1.24e-02	6.07e-01	7.71e-06	7.50e-01



Evaluating how well UKB470K_EAML_Union genes are linked to AoU245K_EAML_Union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB470K_EAML_Union Exclusive	AoU245K_EAML_Union	0.48	-0.45	-0.63	-0.50	-1.97
AoU245K_EAML_Union Exclusive	UKB470K_EAML_Union	0.50	-1.94	-1.11	-1.62	0.30
UKB470K_EAML_Union Exclusive	AoU245K_EAML_Union Exclusive	0.47	-0.73	-1.12	-0.53	-2.28
AoU245K_EAML_Union Exclusive	UKB470K_EAML_Union Exclusive	0.50	-1.98	-0.73	-1.63	0.26
UKB470K_EAML_Union Exclusive	Overlap	0.61	1.07	1.68	1.08	1.82
AoU245K_EAML_Union Exclusive	Overlap	0.51	-1.46	-1.40	-1.40	0.18
Overlap	Exclusives	0.50	0.55	0.62	0.57	0.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB470K_EAML_Union Exclusive	AoU245K_EAML_Union	0.03	-0.81	-0.36	-0.68	-2.09
AoU245K_EAML_Union Exclusive	UKB470K_EAML_Union	0.02	-1.43	-0.47	-1.34	0.34
UKB470K_EAML_Union Exclusive	AoU245K_EAML_Union Exclusive	0.03	-1.55	-1.29	-1.24	-2.44
AoU245K_EAML_Union Exclusive	UKB470K_EAML_Union Exclusive	0.02	-1.27	-0.32	-1.24	-0.06
UKB470K_EAML_Union Exclusive	Overlap	0.01	3.74	14.39	4.40	14.74
AoU245K_EAML_Union Exclusive	Overlap	0.00	0.43	0.27	-0.15	0.98
Overlap	Exclusives	0.05	0.68	0.92	0.59	0.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB470K_EAML_Union Exclusive	300	295	PRR36;EDDM13;ZNF883;TTC6;AC093155.3
AoU245K_EAML_Union Exclusive	581	572	TEX49;C4orf50;AC005324.3;THEGL;TAF11L11;NPIPB2;OR5D3P;OC90;AKR1C8P
Overlap	21	21