Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Top51_SKATO Exclusive	tier1	7.92e-01	7.66e-01	8.85e-01	6.09e-02
tier1 Exclusive	Top51_SKATO	2.46e-01	7.67e-01	2.69e-01	6.14e-01
Top51_SKATO Exclusive	tier1 Exclusive	6.07e-01	8.03e-01	6.42e-01	1.35e-01
tier1 Exclusive	Top51_SKATO Exclusive	2.24e-01	8.73e-01	7.05e-01	6.69e-01
Top51_SKATO Exclusive	Overlap	5.74e-01	6.10e-01	4.78e-01	4.21e-01
tier1 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	2.49e-07	2.46e-07	5.07e-09	2.67e-08



Evaluating how well Top51_SKATO genes are linked to tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top51_SKATO Exclusive	tier1	0.63	0.74	1.18	0.49	2.71
tier1 Exclusive	Top51_SKATO	0.53	0.83	0.10	0.55	0.72
Top51_SKATO Exclusive	tier1 Exclusive	0.62	0.89	1.12	0.85	2.37
tier1 Exclusive	Top51_SKATO Exclusive	0.51	0.33	-0.30	-0.08	0.23
Top51_SKATO Exclusive	Overlap	0.72	0.97	0.72	0.85	0.85
tier1 Exclusive	Overlap	1.00	2.75	2.34	2.90	2.43
Overlap	Exclusives	0.71	2.42	6.21	3.28	6.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top51_SKATO Exclusive	tier1	0.00	0.42	0.20	0.11	0.58
tier1 Exclusive	Top51_SKATO	0.01	8.16	15.99	13.43	16.42
Top51_SKATO Exclusive	tier1 Exclusive	0.00	0.61	0.33	0.20	0.90
tier1 Exclusive	Top51_SKATO Exclusive	0.00	0.11	0.57	0.03	0.52
Top51_SKATO Exclusive	Overlap	0.00	0.17	-0.16	-0.03	-0.10
tier1 Exclusive	Overlap	0.12	233.77	64.25	213.34	152.83
Overlap	Exclusives	0.09	27.24	172.13	33.41	179.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Top51_SKATO Exclusive	48	44	CTD-2611O12.2;AC008734.1;AC008734.2;CTC-512J12.6
tier1 Exclusive	29	28	MS4A
Overlap	2	2