Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Top51_SKATO	tier2	4.83e-02	2.16e-02	2.57e-02	1.36e-04
tier2	Top51_SKATO	3.04e-01	3.65e-01	8.57e-02	4.23e-01



Evaluating how well Top51_SKATO genes are linked to tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top51_SKATO	tier2	0.67	1.71	2.78	1.85	3.90
tier2	Top51_SKATO	0.54	0.81	0.53	0.54	0.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Top51_SKATO	tier2	0.01	2.97	8.33	4.48	1.26
tier2	Top51_SKATO	0.03	49.10	35.52	30.83	39.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Top51_SKATO	50	46	CTD-2611O12.2;AC008734.1;AC008734.2;CTC-512J12.6
tier2	46	43	TNSF13;TNSF12;IGH